| ONC - BeiGene, Ltd. | | Reduce 8% $(199.5M) | 26.50% | $2.4B | +7.89% | | |
| INCY - Incyte Corporation | | | 20.60% | $1.9B | +2.98% | | |
| ACAD - ACADIA Pharmaceuticals Inc. | | | 7.88% | $712.2M | +17.42% | | |
| MDGL - Madrigal Pharmaceuticals, Inc. | | | 7.24% | $654.0M | -5.87% | | |
| SMMT - Summit Therapeutics Inc. | | | 5.21% | $471.2M | | | |
| INSM - Insmed Incorporated | | Add 7% ($28.5M) | 4.54% | $410.5M | +3.26% | | |
| RYTM - Rhythm Pharmaceuticals, Inc. | | Reduce 8% $(25.4M) | 3.29% | $296.9M | +2.35% | | |
| RVMD - Revolution Medicines, Inc. | | | 3.11% | $280.7M | +0.08% | | |
| KYMR - Kymera Therapeutics, Inc. | | | 1.82% | $164.1M | -0.69% | | |
| ALKS - Alkermes plc | | Add 7% ($10.0M) | 1.64% | $148.0M | | | |
| EWTX - Edgewise Therapeutics, Inc. | | | 1.50% | $135.4M | -1.38% | | |
| REPL - Replimune Group, Inc. | | | 1.19% | $107.7M | +24.55% | | |
| N/A - Insmed Incorporated | | | 1.12% | $101.6M | | | |
| IMVT - Immunovant, Inc. | | Add 220% ($64.1M) | 1.03% | $93.3M | +6.15% | | |
| BCYC - Bicycle Therapeutics plc | | | 1.02% | $92.4M | +1.48% | | |
| IMCR - Immunocore Holdings plc | | Add 53% ($24.0M) | 0.76% | $68.9M | | | |
| KNSA - Kiniksa Pharmaceuticals International, plc | | | 0.69% | $62.6M | +5.68% | | |
| ABCL - AbCellera Biologics Inc. | | | 0.68% | $61.4M | | | |
| RARE - Ultragenyx Pharmaceutical Inc. | | | 0.63% | $57.1M | | | |
| DNLI - Denali Therapeutics Inc. | | | 0.56% | $50.7M | | | |
| KOD - Kodiak Sciences Inc. | | | 0.54% | $48.6M | +3.03% | | |
| NRIX - Nurix Therapeutics, Inc. | | | 0.51% | $46.1M | +12.37% | | |
| ARGX - argenx SE | | Reduce 31% $(20.2M) | 0.51% | $46.0M | +2.22% | | |
| TRDA - Entrada Therapeutics, Inc. | | | 0.49% | $44.0M | -6.40% | | |
| CELC - Celcuity Inc. | | Add 59% ($16.0M) | 0.48% | $43.0M | | | |
| GRAL - GRAIL, Inc. | | | 0.46% | $41.6M | -1.76% | | |
| ROIV - Roivant Sciences Ltd. | | | 0.42% | $38.0M | +2.23% | | |
| IMTX - Immatics N.V. | | | 0.36% | $32.8M | +13.24% | | |
| STOK - Stoke Therapeutics, Inc. | | | 0.34% | $30.8M | -1.85% | | |
| CERS - Cerus Corporation | | Reduce 1% $(175.5K) | 0.30% | $26.9M | -0.78% | | |
| PCVX - Vaxcyte, Inc. | | New Purchase | 0.27% | $24.2M | +4.91% | | |
| GLUE - Monte Rosa Therapeutics, Inc. | | | 0.25% | $22.8M | +7.73% | | |
| CRSP - CRISPR Therapeutics AG | | Reduce 50% $(22.3M) | 0.25% | $22.3M | -2.71% | | |
| AKRO - Akero Therapeutics, Inc. | | Reduce 50% $(22.2M) | 0.25% | $22.2M | +24.06% | | |
| SERA - Sera Prognostics, Inc. | | Add 1% ($234.7K) | 0.22% | $20.2M | | | |
| CNTA - Centessa Pharmaceuticals plc | | | 0.20% | $17.6M | | | |
| NGNE - Neurogene Inc. | | Add 120% ($9.5M) | 0.19% | $17.4M | -6.54% | | |
| IDYA - IDEAYA Biosciences, Inc. | | | 0.19% | $17.4M | +14.90% | | |
| VRNA - Verona Pharma plc | | New Purchase | 0.16% | $14.2M | +16.27% | | |
| CADL - Candel Therapeutics, Inc. | | Reduce 18% $(3.1M) | 0.15% | $13.8M | | | |
| PRAX - Praxis Precision Medicines, Inc. | | | 0.14% | $12.6M | +3.46% | | |
| TSVT - 2seventy bio, Inc. | | New Purchase | 0.14% | $12.3M | | | |
| XENE - Xenon Pharmaceuticals Inc. | | Reduce 65% $(21.7M) | 0.13% | $11.7M | -2.76% | | |
| BCAX - Bicara Therapeutics Inc. | | | 0.12% | $10.9M | -32.82% | | |
| IONS - Ionis Pharmaceuticals, Inc. | | | 0.12% | $10.8M | +1.24% | | |
| DBVT - DBV Technologies S.A. | | New Purchase | 0.11% | $10.0M | -21.60% | | |
| ALMS - Alumis Inc. | | | 0.11% | $9.6M | -34.46% | | |
| MRUS - Merus N.V. | | Reduce 50% $(9.5M) | 0.10% | $9.4M | +40.53% | | |
| PRLD - Prelude Therapeutics Inc. | | | 0.09% | $7.8M | -4.74% | | |
| VERV - Verve Therapeutics, Inc. | | New Purchase | 0.09% | $7.7M | +1.83% | | |
| KRYS - Krystal Biotech, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| IGMS - IGM Biosciences, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| N/A - Ionis Pharmaceuticals, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| XNCR - Xencor, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| DYN - Dyne Therapeutics, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |