| BGNE - BeiGene, Ltd. | | | 24.59% | $2.4B | +30.77% | +26.80% | |
| INCY - Incyte Corporation | | | 21.06% | $2.0B | -15.67% | -7.62% | |
| ACAD - ACADIA Pharmaceuticals Inc. | | | 6.83% | $659.5M | +25.85% | +15.17% | |
| SMMT - Summit Therapeutics Inc. | | Add 5% ($26.3M) | 5.54% | $534.9M | -6.35% | +8.38% | |
| MDGL - Madrigal Pharmaceuticals, Inc. | | | 4.34% | $419.0M | -9.24% | +12.06% | |
| RVMD - Revolution Medicines, Inc. | | | 3.56% | $343.3M | -30.84% | -27.21% | |
| RYTM - Rhythm Pharmaceuticals, Inc. | | | 3.47% | $335.2M | +1.86% | -4.42% | |
| INSM - Insmed Incorporated | | Add 23% ($61.3M) | 3.34% | $322.4M | -3.30% | +12.83% | |
| KYMR - Kymera Therapeutics, Inc. | | | 2.94% | $283.8M | -34.13% | -17.49% | |
| BCYC - Bicycle Therapeutics plc | | | 2.20% | $212.7M | -63.71% | -46.31% | |
| EWTX - Edgewise Therapeutics, Inc. | | | 1.62% | $155.9M | -56.74% | -20.84% | |
| REPL - Replimune Group, Inc. | | Add 10% ($11.0M) | 1.25% | $121.1M | -21.91% | +22.00% | |
| ALKS - Alkermes plc | | | 1.21% | $117.0M | +7.74% | +26.36% | |
| DNLI - Denali Therapeutics Inc. | | | 1.13% | $108.7M | -53.35% | -23.22% | |
| N/A - Insmed Incorporated | | | 1.02% | $98.3M | | | |
| RARE - Ultragenyx Pharmaceutical Inc. | | Add 7% ($6.1M) | 0.91% | $87.6M | -28.15% | -7.90% | |
| NRIX - Nurix Therapeutics, Inc. | | | 0.90% | $87.2M | -59.89% | -36.87% | |
| TRDA - Entrada Therapeutics, Inc. | | | 0.81% | $77.8M | -60.48% | -31.93% | |
| IMTX - Immatics N.V. | | | 0.76% | $73.5M | -36.81% | -43.26% | |
| ABCL - AbCellera Biologics Inc. | | | 0.74% | $71.6M | -26.55% | +24.73% | |
| KNSA - Kiniksa Pharmaceuticals International, plc | | | 0.73% | $70.4M | +24.93% | -10.73% | |
| IGMS - IGM Biosciences, Inc. | | | 0.70% | $67.7M | -87.63% | -85.78% | |
| ARGX - argenx SE | | | 0.63% | $60.7M | +0.15% | +11.63% | |
| STOK - Stoke Therapeutics, Inc. | | | 0.56% | $53.7M | -31.27% | -30.04% | |
| IMCR - Immunocore Holdings plc | | | 0.49% | $47.2M | +11.86% | -10.76% | |
| KOD - Kodiak Sciences Inc. | | | 0.47% | $45.2M | -36.33% | -3.56% | |
| SERA - Sera Prognostics, Inc. | | | 0.44% | $42.4M | -76.29% | -40.58% | |
| CRSP - CRISPR Therapeutics AG | | New Purchase | 0.41% | $39.6M | -23.78% | +9.68% | |
| XENE - Xenon Pharmaceuticals Inc. | | | 0.41% | $39.1M | -30.21% | -5.30% | |
| IMVT - Immunovant, Inc. | | Add 164% ($21.7M) | 0.36% | $34.9M | -46.96% | -25.64% | |
| CERS - Cerus Corporation | | | 0.35% | $33.9M | -30.22% | +2.20% | |
| IDYA - IDEAYA Biosciences, Inc. | | | 0.35% | $33.6M | -32.48% | -30.62% | |
| ROIV - Roivant Sciences Ltd. | | | 0.33% | $32.3M | -4.93% | -7.61% | |
| AKRO - Akero Therapeutics, Inc. | | | 0.33% | $31.5M | +65.67% | +64.96% | |
| KRYS - Krystal Biotech, Inc. | | | 0.32% | $30.9M | -29.38% | -12.15% | |
| CELC - Celcuity Inc. | | | 0.29% | $28.0M | -24.45% | -9.31% | |
| GLUE - Monte Rosa Therapeutics, Inc. | | | 0.27% | $26.1M | -51.23% | -23.57% | |
| DYN - Dyne Therapeutics, Inc. | | | 0.25% | $24.1M | -60.94% | -55.00% | |
| BMEA - Biomea Fusion, Inc. | | | 0.22% | $21.3M | -79.49% | -48.86% | |
| BCAX - Bicara Therapeutics Inc. | | New Purchase | 0.22% | $21.2M | -58.37% | -41.09% | |
| PRLD - Prelude Therapeutics Inc. | | | 0.22% | $21.0M | -15.63% | -9.64% | |
| CNTA - Centessa Pharmaceuticals plc | | New Purchase | 0.20% | $19.6M | -24.06% | -8.60% | |
| NGNE - Neurogene Inc. | | | 0.20% | $19.1M | -56.20% | -55.33% | |
| PRAX - Praxis Precision Medicines, Inc. | | New Purchase | 0.19% | $18.6M | -49.65% | +2.72% | |
| ALMS - Alumis Inc. | | | 0.17% | $16.7M | -63.16% | -46.74% | |
| MRUS - Merus N.V. | | | 0.16% | $15.0M | +13.66% | -14.31% | |
| TCRX - TScan Therapeutics, Inc. | | | 0.14% | $13.9M | -70.52% | -58.56% | |
| NMRA - Neumora Therapeutics, Inc. | | | 0.14% | $13.7M | -93.90% | -85.26% | |
| XNCR - Xencor, Inc. | | Add 23% ($2.5M) | 0.14% | $13.5M | -66.04% | -31.15% | |
| TSVT - 2seventy bio, Inc. | | | 0.12% | $11.8M | | -39.65% | |
| CERE - Cerevel Therapeutics Holdings, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| FATE - Fate Therapeutics, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |
| N/A - Insmed Incorporated | | Reduce 100% | 0.00% | $0.00 | | | |
| SANA - Sana Biotechnology, Inc. | | Reduce 100% | 0.00% | $0.00 | | | |